Chicken Pot Pie Casserole


Transport yourself to cozy evenings and hearty meals with this Chicken Pot Pie Casserole recipe. Packed with tender chicken, vibrant vegetables, creamy sauce, and a golden biscuit topping, this dish is a comforting delight for the whole family. Perfect for weeknight dinners or special occasions, it’s a satisfying meal that brings warmth and flavor to the table. Let’s dive into the details of how to prepare this classic comfort food.


Gather the following ingredients to create this delectable Chicken Pot Pie Casserole:

  • 2 cups chicken, cooked and shredded
  • 1 can (10.5 oz) cream of chicken soup
  • 2 cups mixed vegetables (carrots, peas, green beans, corn), thawed
  • 1 cup cheddar cheese, shredded
  • 1 1/2 cups milk
  • 1 cup Bisquick mix (for the biscuits)
  • 1/2 cup sour cream
  • 1/4 cup butter, melted
  • 1 garlic clove, minced
  • Salt and pepper to taste


Follow these simple steps to create a Chicken Pot Pie Casserole masterpiece:

  1. Preheat your oven to 375°F (190°C) and grease a 9×13 inch baking dish.
  2. In a large mixing bowl, combine the cooked chicken, cream of chicken soup, mixed vegetables, and half of the shredded cheddar cheese. Season with salt and pepper to taste.
  3. Spread the chicken mixture evenly in the prepared baking dish, creating a flavorful base for the casserole.
  4. In another bowl, whisk together the milk, Bisquick mix, sour cream, melted butter, and minced garlic until smooth and well combined.
  5. Pour the biscuit mixture over the chicken layer, spreading it out evenly to cover the surface of the casserole.
  6. Sprinkle the remaining shredded cheddar cheese over the top, adding an extra layer of cheesy goodness.
  7. Bake the casserole in the preheated oven for 30-35 minutes, or until the biscuit topping is golden brown and the filling is bubbly and heated through.
  8. Allow the Chicken Pot Pie Casserole to cool for a few minutes before serving, allowing the flavors to meld together and the dish to set slightly.

Serving and Storage Tips:

  1. Serving Suggestions: Serve the Chicken Pot Pie Casserole hot and fresh from the oven, garnished with freshly chopped parsley for a pop of color and flavor. Pair it with a side salad or steamed vegetables for a complete and balanced meal.
  2. Portion Control: When serving, use a sharp knife to cut the casserole into even portions. A spatula or pie server can then be used to transfer the servings onto individual plates with ease.
  3. Reheating Leftovers: To reheat leftover Chicken Pot Pie Casserole, place individual portions in the microwave for 1-2 minutes or until heated through. Alternatively, you can reheat larger portions in the oven at 350°F (175°C) for about 15-20 minutes or until warmed to your liking.
  4. Storing Leftovers: If you have any leftovers, allow the casserole to cool completely before transferring it to an airtight container. Store the leftovers in the refrigerator for up to 3-4 days. Ensure that the container is tightly sealed to maintain freshness and prevent the casserole from absorbing any odors from the refrigerator.
  5. Freezing Instructions: Chicken Pot Pie Casserole can also be frozen for longer storage. Once cooled, wrap the casserole tightly in plastic wrap or aluminum foil, or transfer it to a freezer-safe container. Label the container with the date and store it in the freezer for up to 2-3 months.
  6. Thawing Frozen Casserole: When ready to enjoy frozen leftovers, transfer the casserole from the freezer to the refrigerator and allow it to thaw overnight. Reheat according to the reheating instructions mentioned above.
  7. Refreshing Leftover Biscuit Topping: If the biscuit topping becomes slightly soggy after refrigeration, you can refresh it by reheating the casserole in the oven at 350°F (175°C) for 10-15 minutes, or until the topping becomes crisp again.
  8. Customization: Feel free to customize the Chicken Pot Pie Casserole with your favorite ingredients or substitutions. You can add additional spices or herbs to the filling for extra flavor or swap out the vegetables for your preferred choices.

By following these serving and storage tips, you can ensure that your Chicken Pot Pie Casserole remains fresh, delicious, and ready to enjoy whenever hunger strikes.


1. Can I use frozen vegetables for Chicken Pot Pie Casserole?

  • Yes, frozen mixed vegetables are a convenient option for this recipe. Simply thaw them before adding them to the casserole mixture.

2. Can I use rotisserie chicken instead of cooking chicken from scratch?

  • Absolutely! Rotisserie chicken can save time and add flavor to the casserole. Simply shred the meat and incorporate it into the recipe as directed.

3. Can I make Chicken Pot Pie Casserole ahead of time?

  • Yes, you can assemble the casserole ahead of time and refrigerate it before baking. When ready to bake, simply preheat the oven and bake as instructed.

4. Can I use a different type of soup instead of cream of chicken soup?

  • Yes, you can substitute cream of mushroom soup or cream of celery soup for a different flavor profile. Choose your favorite option or use what you have on hand.

5. Can I make Chicken Pot Pie Casserole without Bisquick mix?

  • If you don’t have Bisquick mix, you can make a simple biscuit topping from scratch using flour, baking powder, salt, and butter. There are many homemade biscuit recipes available online.

6. Can I freeze Chicken Pot Pie Casserole before baking?

  • Yes, you can freeze the assembled casserole before baking. Wrap it tightly in plastic wrap and aluminum foil, then freeze for up to 3 months. Thaw overnight in the refrigerator before baking.

7. Can I use low-fat or fat-free ingredients to make a healthier version?

  • Yes, you can use low-fat or fat-free versions of ingredients like cream of chicken soup, milk, and sour cream to reduce the fat content of the casserole. However, keep in mind that it may affect the flavor and texture slightly.

8. Can I add extra spices or herbs to the casserole for more flavor?

  • Absolutely! Feel free to customize the seasoning to your taste preferences. Adding herbs like thyme, rosemary, or parsley can enhance the flavor of the casserole.

9. Can I use a different type of cheese instead of cheddar?

  • Yes, you can use your favorite cheese or a combination of cheeses in the casserole. Gouda, mozzarella, or Monterey Jack would all be delicious options.

10. Can I make Chicken Pot Pie Casserole in a smaller or larger size?

  • Yes, you can adjust the size of the casserole by using a smaller or larger baking dish and adjusting the ingredient quantities accordingly. Just be sure to monitor the cooking time accordingly to ensure it cooks evenly.


With its comforting flavors and hearty ingredients, Chicken Pot Pie Casserole is a timeless favorite that never fails to satisfy. Whether you’re craving a cozy weeknight meal or planning a gathering with loved ones, this recipe is sure to please. Serve up a generous portion of this delicious casserole and enjoy the warmth and comfort it brings to your table.

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