1. Mix the filling: In a medium-sized bowl, combine the softened cream cheese, pizza sauce, and Italian seasoning. Stir until the mixture is smooth and evenly combined.
2. Assemble the pinwheels: Lay one tortilla flat on a clean surface. Spread 1/4 of the cream cheese mixture evenly over the entire surface of the tortilla.
3. Add the toppings: Sprinkle 2 oz of shredded mozzarella cheese evenly over the tortilla. Arrange 6 slices of pepperoni in a single layer on top of the cheese.
4. Roll and chill: Tightly roll up the tortilla from one side to the other. Wrap the roll in plastic wrap and refrigerate for at least 1 hour. This helps the pinwheels stay intact when sliced.
5. Slice and serve: Remove the roll from the refrigerator and unwrap the plastic. Use a sharp knife to cut the roll into 1-inch slices. Arrange the pinwheels flat on a serving platter.
6. Enjoy: Serve these cold pepperoni pizza pinwheels as a party appetizer or snack. Enjoy!

Pro Tip: You can prepare these pinwheels up to 24 hours in advance. Store them covered in the refrigerator until ready to serve.