Southern Brisket Grilled Cheese


Prepare to tantalize your taste buds with a Southern twist on a classic comfort food favorite – the Southern Brisket Grilled Cheese. This mouthwatering sandwich combines tender, smoky brisket, gooey melted cheese, and tangy barbecue sauce, all sandwiched between buttery, toasted bread. Whether you’re a grilled cheese aficionado or a barbecue lover looking for a new way to enjoy your favorite flavors, this recipe is sure to become a staple in your culinary repertoire. Join us as we explore the magic of Southern Brisket Grilled Cheese and learn how to create this irresistible dish in your own kitchen.

The Allure of Southern Brisket Grilled Cheese: Southern Brisket Grilled Cheese offers the perfect marriage of savory, smoky, and cheesy flavors, all packed into one delicious sandwich. The tender, slow-cooked brisket pairs beautifully with the creamy melted cheese, while the tangy barbecue sauce adds a burst of flavor with every bite. Whether served as a hearty lunch, a comforting dinner, or a crowd-pleasing appetizer, this grilled cheese creation is guaranteed to satisfy even the most discerning palates.

Crafting the Perfect Southern Brisket Grilled Cheese: Get ready to embark on a culinary adventure with our simple yet sensational recipe for Southern Brisket Grilled Cheese. Here’s what you’ll need:


  • 8 slices of your favorite bread (such as Texas toast or sourdough)
  • 2 cups shredded brisket (leftover or store-bought)
  • 2 cups shredded cheese (cheddar, Monterey Jack, or a combination)
  • 1/2 cup barbecue sauce
  • Butter, softened


  1. Heat a skillet or griddle over medium heat.
  2. Butter one side of each slice of bread.
  3. Place a slice of bread, buttered side down, onto the skillet.
  4. Top the bread with a layer of shredded cheese, followed by a generous portion of shredded brisket.
  5. Drizzle barbecue sauce over the brisket.
  6. Top with another layer of shredded cheese.
  7. Place another slice of bread on top, buttered side up.
  8. Cook the sandwich for 3-4 minutes on each side, or until the bread is golden brown and the cheese is melted.
  9. Remove the sandwich from the skillet and let it cool for a minute or two before slicing.
  10. Serve hot and enjoy the gooey, savory goodness of Southern Brisket Grilled Cheese!

Serving and Storage Tips:

Serving Tips:

  1. Serve Immediately: Southern Brisket Grilled Cheese is best served hot and fresh off the skillet to enjoy its gooey, savory goodness to the fullest. Serve it immediately after cooking for the best taste and texture.
  2. Slice Before Serving: To make it easier for your guests to enjoy, slice the grilled cheese sandwiches diagonally or into halves before serving. This allows for easier handling and sharing.
  3. Pair with Side Dishes: Round out your meal by serving Southern Brisket Grilled Cheese with complementary side dishes such as coleslaw, potato chips, or a crisp green salad. These sides add variety and balance to the meal.
  4. Serve with Dipping Sauce: Offer barbecue sauce or ranch dressing on the side for dipping. This adds an extra layer of flavor and enhances the overall enjoyment of the sandwich.

Storage Tips:

  1. Refrigerate Leftovers Promptly: If you have leftover Southern Brisket Grilled Cheese, wrap each sandwich individually in aluminum foil or plastic wrap and refrigerate them promptly to maintain their freshness.
  2. Reheat with Care: When reheating leftover grilled cheese sandwiches, use a skillet or toaster oven to gently warm them until heated through. Avoid using the microwave, as it can make the bread soggy.
  3. Freeze for Longer Storage: If you want to store Southern Brisket Grilled Cheese for an extended period, wrap each sandwich tightly in plastic wrap and aluminum foil, then place them in a freezer-safe container or resealable freezer bag. They can be frozen for up to 1-2 months.
  4. Thaw Before Reheating: When ready to enjoy frozen grilled cheese sandwiches, thaw them overnight in the refrigerator before reheating. This helps prevent the bread from becoming overly soggy during reheating.
  5. Refresh Before Serving: Before reheating leftover grilled cheese sandwiches, consider refreshing them by adding a thin layer of butter to the outsides of the bread before reheating. This helps restore their crispiness and enhances their flavor.

By following these serving and storage tips, you can ensure that your Southern Brisket Grilled Cheese remains fresh, flavorful, and ready to enjoy whenever the craving strikes. Whether serving them to guests or savoring them as a quick and satisfying meal, these grilled cheese sandwiches are sure to be a hit.


  1. Can I use any type of bread for Southern Brisket Grilled Cheese?
    • Yes, you can use your favorite type of bread for this recipe. Popular options include Texas toast, sourdough, ciabatta, or French bread. Choose a bread that you enjoy and that can hold up to the hearty filling.
  2. What type of barbecue sauce works best for this recipe?
    • You can use any type of barbecue sauce that you prefer, whether it’s sweet, spicy, or tangy. Popular options include hickory-smoked, Kansas City-style, or Texas-style barbecue sauce. Feel free to experiment with different flavors to find your favorite.
  3. Can I make Southern Brisket Grilled Cheese ahead of time for a party?
    • While Southern Brisket Grilled Cheese is best enjoyed fresh off the skillet, you can prepare the brisket and cheese filling ahead of time and assemble the sandwiches just before serving. Keep the components separate and assemble them when you’re ready to cook.
  4. Can I use leftover brisket for this recipe?
    • Absolutely! Using leftover brisket is a great way to repurpose leftovers into a delicious meal. Simply shred the brisket and reheat it before assembling the sandwiches.
  5. Is it necessary to butter the bread before grilling?
    • Buttering the bread before grilling adds flavor and helps achieve a crispy, golden-brown exterior. However, if you prefer a lighter option, you can skip the butter or use a non-stick cooking spray instead.
  6. What type of cheese melts best for Southern Brisket Grilled Cheese?
    • Cheese that melts well and complements the flavors of brisket and barbecue sauce works best for this recipe. Cheddar, Monterey Jack, provolone, or pepper jack are all excellent choices. You can also use a combination of cheeses for added flavor complexity.
  7. Can I make Southern Brisket Grilled Cheese on a panini press?
    • Yes, you can use a panini press to make Southern Brisket Grilled Cheese. Simply assemble the sandwiches as instructed, then grill them in the panini press until the bread is golden brown and the cheese is melted.
  8. Can I make Southern Brisket Grilled Cheese vegetarian?
    • Yes, you can make a vegetarian version of this recipe by omitting the brisket and using grilled vegetables, such as mushrooms, bell peppers, and onions, as the filling. You can also add vegetarian bacon or plant-based protein alternatives for added flavor and texture.
  9. How can I prevent the barbecue sauce from making the bread soggy?
    • To prevent the barbecue sauce from making the bread soggy, spread a thin layer of butter on the inside of each bread slice before assembling the sandwiches. This creates a barrier between the bread and the sauce, helping to maintain its crispness.
  10. Can I customize the sandwich with additional toppings?
    • Absolutely! Feel free to customize your Southern Brisket Grilled Cheese with additional toppings such as sliced tomatoes, avocado, caramelized onions, or crispy bacon for added flavor and texture.


With its irresistible combination of tender brisket, melted cheese, and tangy barbecue sauce, Southern Brisket Grilled Cheese is a surefire crowd-pleaser that will leave you craving more. Whether you’re enjoying it as a comforting meal at home or serving it up at your next gathering, this sandwich is guaranteed to be a hit. By following our simple recipe and customization tips, you can create a grilled cheese masterpiece that will have everyone coming back for seconds. So why wait? Fire up the skillet and get ready to savor the deliciousness of Southern Brisket Grilled Cheese today!

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